Key result
High abdominal subcutaneous and visceral adipose tissue thickness in early pregnancy were associated with increased risk of GDM (OR 3.42, 95% CI 2.31-5.07 and OR 5.73, 95% CI 3.39-9.77, respectively).
Why the study?
Obesity is linked to gestational diabetes mellitus risk, but the predictive role of ultrasonographic abdominal adipose tissue thickness measurements required assessment.
Does high ultrasonographic abdominal adipose tissue thickness predict gestational diabetes mellitus in pregnant women?
Meta-Analysis (n=5,616)
Does high ultrasonographic abdominal adipose tissue thickness predict gestational diabetes mellitus in pregnant women?
Odds Ratio: 3.42 (95% CI 2.31–5.07)
p-value: p=<0.001
Ultrasound-measured abdominal adipose tissue thickness at early stages of pregnancy may be useful for predicting the subsequent risk of gestational diabetes mellitus.
SAT/VAT thickness was associated with higher GDM risk; leaves open whether ultrasound improves prediction beyond standard factors.
Obesity has been linked to the risk of gestational diabetes mellitus (GDM). The meta-analysis aimed to assess the predictive role of ultrasonographic measurements of the abdominal adipose tissue thickness for GDM in pregnant women. Cohort studies evaluating the association between abdominal subcutaneous and/or visceral adipose thickness (SAT and/or VAT) and subsequent risk of GDM were retrieved from PubMed, Embase, and Web of Science databases. Only studies with SAT/VAT measured before the diagnosis of GDM were included. Random-effects models incorporating the influence of potential heterogeneity were used to pool the results. A total of 13 studies involving 5616 pregnant women were included. Pooled results showed that both a high abdominal SAT (odds ratio [OR] for per 1-cm increment: 1.23, 95% confidence interval [CI]: 1.07 to 1.41, P = 0.003, I2 = 13%; OR for high versus low category: 3.42, 95% CI: 2.31 to 5.07, P < 0.001, I2 = 0%) and VAT (OR for per 1-cm increment: 1.54, 95% CI: 1.16 to 2.06, P = 0.003, I2 = 63%; OR for high versus low category: 5.73, 95% CI: 3.39 to 9.77, P < 0.001, I2 = 31%) at early stages of pregnancy were associated with a higher subsequent risk of GDM. Subgroup analysis based on study design, timing of ultrasound examination, GDM diagnostic criteria, and study quality score showed consistent results. In conclusion, ultrasound-measured abdominal adipose tissue thickness may be useful for predicting the subsequent risk of GDM in pregnant women.
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Hou et al. (2023) conducted a meta-analysis in Gestational diabetes mellitus (GDM) (n=5,616). High abdominal subcutaneous adipose thickness (SAT) vs. Low abdominal subcutaneous adipose thickness (SAT) was evaluated on Subsequent risk of gestational diabetes mellitus (OR 3.42, 95% CI 2.31 to 5.07, p=<0.001). High abdominal subcutaneous and visceral adipose tissue thickness in early pregnancy were associated with increased risk of GDM (OR 3.42, 95% CI 2.31-5.07 and OR 5.73, 95% CI 3.39-9.77, respectively).
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