Key result
The PAI-1 rs1799889 polymorphism was not significantly associated with venous thromboembolism overall (N=14,806), but was significantly associated in Caucasians, East Asians, and for DVT.
Why the study?
This study was conducted to better assess the relationship between plasminogen activator inhibitor-1 (PAI-1) rs1799889 polymorphism and the risk of venous thromboembolism.
Is the PAI-1 rs1799889 polymorphism associated with an increased risk of venous thromboembolism?
Meta-Analysis (n=14,806)
Is the PAI-1 rs1799889 polymorphism associated with an increased risk of venous thromboembolism?
The PAI-1 rs1799889 polymorphism may serve as a potential biological marker for venous thromboembolism risk specifically in Caucasian and East Asian populations.
Does not support routine PAI-1 testing for VTE; leaves open ancestry-specific associations pending prospective validation.
Background We performed this meta-analysis to better assess the relationship between plasminogen activator inhibitor-1 ( PAI-1) rs1799889 polymorphism and the risk of venous thromboembolism. Method Eligible studies were searched in PubMed, Medline, Embase, Web of Science and CNKI. Odds ratios with 95% confidence intervals were calculated. Result A total of 48 studies with 14,806 participants were analyzed. No positive results were detected in overall analyses. Further subgroup analyses revealed that the PAI-1 rs1799889 polymorphism was significantly associated with the risk of venous thromboembolism in Caucasians and East Asians. When we stratified available data according to type of disease, we found that the PAI-1 rs1799889 polymorphism was significantly correlated with the risk of DVT. No any other positive results were observed in overall and subgroup analyses. Conclusion Our findings indicate that the PAI-1 rs1799889 polymorphism may serve as a potential biological marker for venous thromboembolism in Caucasians and East Asians.
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Geng et al. (2020) conducted a meta-analysis in venous thromboembolism (n=14,806). PAI-1 rs1799889 polymorphism was evaluated on venous thromboembolism. The PAI-1 rs1799889 polymorphism was not significantly associated with venous thromboembolism overall (N=14,806), but was significantly associated in Caucasians, East Asians, and for DVT.
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