Population
Isolated dog's tail perfused with Ringer's solution or plasma
Comparison
Renin (from hog kidneys) mixed with plasma vs Renin in saline, boiled renin with plasma, or…
Design
Preclinical
Authors
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Renin requires plasma cofactor for vasoconstriction; leaves open precise translation to contemporary RAS-targeted therapies.
This historical experiment demonstrated that renin requires a plasma component to produce vasoconstriction, leading to the discovery of angiotensin.
O. M. Helmer (1962) studied this question.