Key result
Eight weeks of exercise training significantly decreased mean arterial pressure (139 vs 157 mmHg) in 2K1C renovascular hypertensive rats.
Why the study?
Does exercise training reduce mean arterial pressure and renal sympathetic nerve activity in a rat model of renovascular hypertension?
Does exercise training reduce mean arterial pressure and renal sympathetic nerve activity in a rat model of renovascular hypertension?
Exercise training attenuates renovascular hypertension and sympathetic overactivity in rats, likely by modulating the renin-angiotensin system, oxidative stress, and glutamate pathways in the paraventricular nucleus.
Answers are grounded in this paper and cite their sources.
Supports exercise training in renovascular hypertension models; leaves open translation to patients.
Exercise training (ExT) has been reported to benefit hypertension; however, the exact mechanisms involved are unclear. We hypothesized that ExT attenuates hypertension, in part, through the renin-angiotensin system (RAS), reactive oxygen species (ROS), and glutamate in the paraventricular nucleus (PVN). Two-kidney, one-clip (2K1C) renovascular hypertensive rats were assigned to sedentary (Sed) or treadmill running groups for eight weeks. Dizocilpine (MK801), a glutamate receptor blocker, or losartan (Los), an angiotensin II type1 receptor (AT1-R) blocker, were microinjected into the PVN at the end of the experiment. We found that 2K1C rats had higher mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA). These rats also had excessive oxidative stress and overactivated RAS in PVN. Eight weeks of ExT significantly decreased MAP and RSNA in 2K1C hypertensive rats. ExT inhibited angiotensin-converting enzyme (ACE), AT1-R, and glutamate in the PVN, and angiotensin II (ANG II) in the plasma. Moreover, ExT attenuated ROS by augmenting copper/zinc superoxide dismutase (Cu/Zn-SOD) and decreasing p47phox and gp91phox in the PVN. MK801or Los significantly decreased blood pressure in rats. Together, these findings suggest that the beneficial effects of ExT on renovascular hypertension may be, in part, through the RAS-ROS-glutamate pathway in the PVN.
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Zhang et al. (2016) studied Renovascular hypertension. Exercise training vs. Sedentary was evaluated on Mean arterial pressure (MAP) (p=<0.05). Eight weeks of exercise training significantly decreased mean arterial pressure (139 vs 157 mmHg) in 2K1C renovascular hypertensive rats.
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