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Zebrafish serve as a useful genetic model for understanding the pathological mechanisms of muscular dystrophies and congenital myopathies, including muscle attachment failure.
Zebrafish are emerging as a valuable genetic model for understanding the pathological mechanisms of muscular dystrophies and congenital myopathies.
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Supports zebrafish models for myopathy mechanisms; extends preclinical tools while leaving clinical translation open.
The muscular dystrophies and congenital myopathies are inherited diseases of the skeletal muscle, which lead to a loss of muscle function and are often fatal. While many of the loci involved are already known, these conditions remain incurable, and genetic models are being developed in an effort to understand the pathological mechanisms involved. Recently several papers have shown that the zebrafish, which is now widely used in developmental genetic studies, will provide a useful addition to our toolkit in this regard. Here we describe these studies, including a zebrafish model of what is potentially the novel pathological mechanism of muscle attachment failure in Duchenne and other muscular dystrophies.
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Bassett et al. (2003) conducted a review in Muscular dystrophies and congenital myopathies. Zebrafish model was evaluated. Zebrafish serve as a useful genetic model for understanding the pathological mechanisms of muscular dystrophies and congenital myopathies, including muscle attachment failure.
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