Investigating the fate of Zirconium-89 labelled antibody in cynomolgus macaques

This is the authors' abstract. We don't add key points for this paper.

BACKGROUND: Zr (Zirconium-89) -labelled anti-KLH human IgG and its metabolites to confirm their non-specific/physiological accumulation in healthy cynomolgus macaques. The anti-KLH antibody was used as a negative control, ensuring that the observed distribution reflected general IgG behavior rather than antigen-specific accumulation. This provides a valuable reference for comparing the biodistribution of targeted antibodies. METHODS: Zr- labelled IgG, was also assessed. RESULTS: Zr]Zr-oxalate was highly accumulated in the epiphysis of the long bones and vertebral body. CONCLUSION: Zr- labelled IgG.