What question did this study set out to answer?

To engineer complex, heterotypic tumor microenvironments in vitro by freeform direct printing of vascular networks and tumor aggregates within photostabilized microgel matrices.

January 1, 2021Biomaterials ScienceOpen Access

Heterotypic tumor models through freeform printing into photostabilized granular microgels

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Authors

TMThomas G. MolleyUNSW Sydney GJGagan K. JalandhraThe University of Sydney SNStephanie NemecUNSW Sydney

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Implication

Tissue engineering study demonstrates 3D freeform printing of perfusable vascularized tumor microenvironments, indicating new pathways for modeling cancer invasion and drug discovery.

Key Points

To engineer complex, heterotypic tumor microenvironments in vitro by freeform direct printing of vascular networks and tumor aggregates within photostabilized microgel matrices.
Formulated photocrosslinkable granular microgels mixed with stromal cells to provide tunable mechanical stability and 3D cellular support.
Directly printed sacrificial Pluronic ink into the cell-laden microgel suspension to form interconnected channels for subsequent endothelialization.
Embedded melanoma cell aggregates at targeted spatial locations relative to the printed channels to evaluate localized tumor behavior.
Successfully created perfusable, endothelialized vascular channels within a stromal-cell-laden microgel matrix.
Melanoma cell migration into the engineered vessels occurred as a function of spatial proximity, establishing a quantifiable measure of invasive potential.

Cite This Study

Molley et al. (2021) studied this question.

synapsesocial.com/papers/6a98d75ae8ca4d2af6362363 https://doi.org/10.1039/d1bm00574j

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Implication

Tissue engineering study demonstrates 3D freeform printing of perfusable vascularized tumor microenvironments, indicating new pathways for modeling cancer invasion and drug discovery.

Heterotypic tumor models through freeform printing into photostabilized granular microgels

Discussion

Member takes

Implication

Key Points

Cite This Study

Heterotypic tumor models through freeform printing into photostabilized granular microgels

Discussion

Member takes

Implication

Key Points

Cite This Study

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