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CD45, a family of hematopoietic cell specific surface antigens, is the best characterized protein tyrosine phosphatase described to date. Considerable evidence from a number of laboratories suggests that surface expression of this molecule is required for normal signaling events to occur in T lymphocytes, B lymphocytes, and natural killer cells. In this paper, data supporting this contention are reviewed and a model proposing how CD45 may exert its regulatory function on signal transduction via the T cell antigen receptor is presented.— Koretzky, G. A. Role of the CD45 tyrosine phosphatase in signal transduction in the immune system. FASEB J. 7: 420‐426; 1993.
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Gary A. Koretzky (1993) studied this question.
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