Key result
Decreasing internal Cs+ from 125 to 8 mM reduced Mg2+ IC50 by 1.4-fold at -105 mV and 11.5-fold at -15 mV, showing permeant ions modulate Mg2+ inhibition of NMDA currents.
Population
Cultured rat cortical neurons
Design
Preclinical
Authors
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No immediate clinical implications from rat neuron data; leaves open physiological relevance of permeant ion effects on NMDA currents.
Permeant ions such as internal Cs+ and external Na+ modulate the voltage-dependent inhibition of NMDA receptors by external Mg2+ in rat cortical neurons.
Qian et al. (2002) studied this question. Permeant ion concentration changes was evaluated on Mg2+ IC50 of NMDA-activated currents. Decreasing internal Cs+ from 125 to 8 mM reduced Mg2+ IC50 by 1.4-fold at -105 mV and 11.5-fold at -15 mV, showing permeant ions modulate Mg2+ inhibition of NMDA currents.
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