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November 1, 2024Annals of Cardiothoracic SurgeryOpen Access

Donation after circulatory death (DCD) presents a promising approach to expand the donor pool for heart transplantation, with short and intermediate outcomes matching those of donation after brain death.

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Why the study?

Despite increasing heart transplant volume worldwide, long-term outcomes, best practices, and standardization for heart transplantation using donation after circulatory death remain to be defined.

Population

Adults in need of heart transplantation and potential donors after circulatory death

Design

Review

Key result

Donation after circulatory death (DCD) presents a promising approach to expand the donor pool for heart transplantation, with short and intermediate outcomes matching those of donation after brain death.

Authors

TRTanisha RajahDBDavid BlitzerSSScott Silvestry

Discussion

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Member takes

Overview

DCD heart transplantation expands donor access; leaves open long-term outcomes and optimal practices.

Structured PICO

P
Population
Adults in need of heart transplantation and potential donors after circulatory death
I
Intervention
Heart transplantation utilizing donors after circulatory death (DCD) via direct procurement and perfusion (DPP) or thoracoabdominal normothermic regional perfusion (TA-NRP)

Expanding heart donation after circulatory death offers a viable solution to the donor shortage, though it requires significant resource allocation and standardization of procurement protocols.

Limitations

  • Long-term outcomes and best practices remain to be defined.
  • Considerable variability exists in regulatory frameworks, professional guidelines, and documented practices.
  • Ethical concerns remain regarding re-establishing a heartbeat and circulation in a person pronounced dead.
  • Limited sample sizes in current studies warrant further investigation.

Cite This Study

Rajah et al. (2024) conducted a review in End-stage heart failure requiring heart transplantation. Donation after circulatory death (DCD) vs. Donation after brain death (DBD) was evaluated. Donation after circulatory death (DCD) presents a promising approach to expand the donor pool for heart transplantation, with short and intermediate outcomes matching those of donation after brain death.

synapsesocial.com/papers/6a98dd7315797dc76eaa850dhttps://doi.org/10.21037/acs-2024-dcd-0069
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Financial impact of donation after circulatory death heart transplantation: A single‐center analysis2024 · 14 citations
  2. 2Utilization of Hearts Donated After Circulatory Death Improves All-Cause Survival in Candidates With Durable Left Ventricular Assist Devices2025
  3. 3Utilization of Hearts Donated After Circulatory Death Improves All-Cause Survival in Candidates With Durable Left Ventricular Assist Devices2025
  4. 4Beyond the learning curve: Advances and ongoing controversies in donation after circulatory-death liver transplantation2026 · 1 citations
  5. 5Logistics for expanding heart transplantation from donation after circulatory death using normothermic regional perfusion2022 · 12 citations