A Simple, Chiral-Pool-Independent Synthesis of Enantiomerically Pure Alanine-Derived α-Amino Aldehyde Acetals

All articles of this category Enantiomerically pure ( R )- or ( S )-1,1-dialkoxy-2-propanamines 5 are obtained in good chemical and optical yields, by asymmetric reduction of chiral imines prepared from 1,1-dialkoxy-2-propanones, using ( R )- or ( S )-1-phenylethylamine (( R )- or ( S )- 2 ) as an inexpensive, efficient chiral auxiliary.