Key result
Amyloidosis significantly impaired left ventricular global longitudinal strain compared to healthy controls (SMD -1.80; 95% CI -2.35 to -1.24; P<0.001), with relative apical sparing.
Why the study?
Studies have used speckle tracking echocardiography or cardiac magnetic resonance to measure left ventricular mechanics in amyloidosis, but the overall influence on global and regional longitudinal strain needed assessment.
Does amyloidosis impair left ventricular global and regional longitudinal strain measured by STE or CMR compared to healthy controls?
Meta-Analysis (n=1,128)
Does amyloidosis impair left ventricular global and regional longitudinal strain measured by STE or CMR compared to healthy controls?
Standardized Mean Difference: -1.8 (95% CI -2.35–-1.24)
p-value: p=<0.001
Amyloidosis significantly impairs left ventricular global longitudinal strain, predominantly affecting basal and mid segments with relative apical sparing, as detected by both STE and CMR.
Reinforces apical-sparing strain pattern as diagnostic hallmark in amyloidosis; extends pooled evidence for GLS monitoring across STE and CMR.
BACKGROUND: Over the last decade, a small number of studies have used speckle tracking echocardiography (STE) or cardiac magnetic resonance (CMR) for measuring left ventricular (LV) mechanics in patients with amyloidosis. This systematic review and meta-analysis aimed at assessing the overall influence of amyloidosis on LV global longitudinal strain (GLS) and regional longitudinal strain at basal (BLS), mid (MLS) and apical (ALS) level, respectively.METHODS: All imaging studies assessing LV-GLS, LV-BLS, LV-MLS and LV-ALS in amyloidosis patients versus healthy controls, selected from PubMed and EMBASE databases, were included. The risk of bias was assessed by using the National Institutes of Health (NIH) Quality Assessment of Case-Control Studies. Continuous data (LV-GLS, LV-BLS, LV-MLS and LV-ALS) were pooled as a standardized mean differences (SMDs) comparing amyloidosis group with healthy controls. The overall SMDs of LV-GLS, LV-BLS, LV-MLS and LV-ALS were calculated using the random-effect model.RESULTS: The full-texts of 13 studies with 553 amyloidosis patients and 575 healthy controls were analyzed. STE (53.8%) and CMR (46.2%) studies were separately analyzed. Average LV-GLS magnitude was significantly impaired in amyloidosis patients vs. controls in both STE (13.8±3.9 vs. 19.8±2.7%) and CMR (12.3±4 vs. 17.9±3.5%) studies. The impairment of segmental strain detected in amyloidosis patients was prevalent at basal and mid level, with relative “apical sparing.” SMDs obtained for LV-GLS (SMD -1.80, 95% CI: -2.35, -1.24, P <0.001), LV-BLS (-1.98; 95% CI: -2.51, -1.45, P <0.001) and LV-MLS (-1.84; 95% CI: -2.46, -1.23, P <0.001) assessment were significantly larger than that obtained for LV-ALS (-0.72; 95% CI: -1.31, -0.13, P=0.02) measurement. Substantial heterogeneity was found among the studies assessing LV-GLS (I2=92.5%), LV-BLS (I2=91.4%), LV-MLS (I2=94.3%) and LV-ALS (I2=94.6%). Egger’s test yielded a P value of 0.10, 0.20, 0.09 and 0.55 for LV-GLS, LV-BLS, LV-MLS and LV-ALS assessment respectively, indicating no publication bias. On meta-regression analysis, none of the moderators was significantly associated with effect modification for LV-GLS, LV-BLS, LV-MLS and LV-ALS (all P<0.05).CONCLUSIONS: Amyloidosis has a large negative effect on LV-GLS, primarily related to the deterioration of segmental longitudinal strain at the basal and mid level, with relative apical sparing.
No takes yet. Share an insight, caveat, or question.
Sonaglioni et al. (2025) conducted a meta-analysis in Amyloidosis (n=1,128). Amyloidosis vs. Healthy controls was evaluated on Left ventricular global longitudinal strain (LV-GLS) (SMD -1.80, 95% CI -2.35, -1.24, p=<0.001). Amyloidosis significantly impaired left ventricular global longitudinal strain compared to healthy controls (SMD -1.80; 95% CI -2.35 to -1.24; P<0.001), with relative apical sparing.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: