Key result
Treatment with ultrasound-guided pericardial injection of cisplatin combined with systemic gemcitabine and lobaplatin maintained the patient in good condition over an 8-month follow-up.
Why the study?
High-stage endometrial carcinoma rarely metastasizes to the pericardium, but such metastases are usually fatal.
Does pericardiocentesis with intrapericardial cisplatin and systemic gemcitabine/lobaplatin improve outcomes in a patient with endometrial carcinoma and malignant pericardial effusion?
Case Report (n=1)
No
Does pericardiocentesis with intrapericardial cisplatin and systemic gemcitabine/lobaplatin improve outcomes in a patient with endometrial carcinoma and malignant pericardial effusion?
Intrapericardial cisplatin combined with systemic gemcitabine and lobaplatin may be an effective treatment strategy for malignant pericardial effusion secondary to endometrial carcinoma.
Hypothesis-generating for combined intrapericardial-systemic chemotherapy in endometrial carcinoma effusion; prospective validation required before adoption.
RATIONALE: High-stage endometrial carcinoma is an aggressive tumor with a high propensity for distant spread. However, metastases to the pericardium are rare in gynecological cancer, and are usually fatal. PATIENT CONCERNS: A 69-year-old woman was diagnosed with endometrial carcinoma with pericardium metastasis. The symptoms at presentation were panic and shortness of breath. DIAGNOSES: The cytologic examination of pericardial fluid obtained by pericardiocentesis confirmed metastasis. INTERVENTIONS: In addition to cisplatin instilled into the pericardial space, for systemic chemotherapy, we chose that gemcitabine and lobaplatin regimen be preferred. OUTCOMES: The patient has been participating in telephone follow-up for 8 months and has generally remained in a good condition. LESSONS: Endometrial carcinoma can have pericardial metastases. When this happens, we recommend ultrasound-guided pericardial puncture and the pericardial injection of cisplatin, in combination with systemic chemotherapy that consists of gemcitabine and lobaplatin.
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Guang et al. (2019) conducted a case report in Endometrial carcinoma with pericardial metastasis (n=1). Pericardial injection of cisplatin combined with systemic gemcitabine and lobaplatin was evaluated on Patient condition and survival. Treatment with ultrasound-guided pericardial injection of cisplatin combined with systemic gemcitabine and lobaplatin maintained the patient in good condition over an 8-month follow-up.
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