Chemosensitive medullary neurones in the brainstem‐‐spinal cord preparation of the neonatal rat.

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Population

Isolated medulla and spinal cord preparation of the neonatal rat

Comparison

Changing CO2 concentration from 2 to 8% in… vs Baseline and testing in the presence of synaptic…

Design

Preclinical

Authors

Discussion

Neonatal rat slice data leave open intrinsic CO2 chemosensitivity in adult human chemoreception; no practice change warranted.

Population

Isolated medulla and spinal cord preparation of the neonatal rat

Intervention

Changing CO2 concentration from 2 to 8% in superfusate

Comparator

Baseline (2% CO2) and testing in the presence of synaptic blockers (tetrodotoxin, low Ca2+-high Mg2+, or Cd2+)

Outcome

Changes in membrane potential and discharge patterns (phrenic burst frequency and amplitude)surrogate

Ventral medullary neurones in neonatal rats demonstrate intrinsic chemosensitivity to CO2, likely mediated by surface dendritic projections.

Kawai et al. (1996) studied this question.

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