Key result
Cytoreductive surgery followed by doxorubicin and ifosfamide chemotherapy resulted in a complete response and 26 months of disease-free survival in a patient with primary cardiac sarcoma.
Why the study?
Undifferentiated pleomorphic sarcoma is a very rare, aggressive primary cardiac tumor with typical median survival of 6 to 12 months, prompting this report of unusually long disease-free survival.
Case Report (n=1)
No
Cytoreductive surgery combined with doxorubicin and ifosfamide chemotherapy can lead to complete response and prolonged disease-free survival in rare primary cardiac undifferentiated pleomorphic sarcoma.
BACKGROUND: Undifferentiated pleomorphic sarcoma is a very rare and aggressive type of primary cardiac tumors. Most cardiac sarcomas result in rapid growth and quick death. According to different sources the median survival is typically 6 to 12 months. We are presenting a case of primary cardiac sarcoma with 26 months disease free survival following cytoreductive surgery and chemotherapy. CASE PRESENTATION: A 48-year-old woman with progressing symptoms of dyspnea and palpitations for over 2 months was referred to a cardiologist. With the help of echocardiography and cardiovascular magnetic resonance cardiac sarcoma was suspected. Open biopsy and cytoreductive surgery were performed, complete resection of the tumor was not possible. Histology revealed undifferentiated pleomorphic sarcoma. Seven cycles of chemotherapy with Doxorubicine and Ifosfamide were completed. Cardiovascular magnetic resonance revealed a complete response - only signs of fibrosis without any signs of tumor were visible. Follow ups with echocardiography, cardiovascular magnetic resonance and chest, abdomen and pelvic computed tomography is performed every 3 months. Twenty-six months from initial diagnosis the patient is still free of recurrence of tumor with no compromises of the quality of life. CONCLUSION: Standard chemotherapy together with cytoreductive surgery can have a complete response effect in undifferentiated pleomorphic sarcoma with unusual long-term survival.
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Vaitiekienė et al. (2019) conducted a case report in Primary cardiac sarcoma (Undifferentiated pleomorphic sarcoma) (n=1). Cytoreductive surgery and chemotherapy (doxorubicin and ifosfamide) was evaluated on Disease-free survival. Cytoreductive surgery followed by doxorubicin and ifosfamide chemotherapy resulted in a complete response and 26 months of disease-free survival in a patient with primary cardiac sarcoma.
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