Key result
Prediabetes significantly increased the risk of the primary composite endpoint of cardiovascular death, myocardial infarction, or stroke compared to normoglycemia in patients with acute myocardial infarction (OR 2.787).
Why the study?
Prediabetes is associated with increased CVD risk and mortality, with risk beginning during the progression from normal glucose tolerance to diabetes, but its impact needed evaluation in newly diagnosed AMI.
Does prediabetes increase the risk of cardiovascular death, myocardial infarction, or stroke in patients presenting with acute myocardial infarction?
Cohort (n=332)
Single-blind
No
Does prediabetes increase the risk of cardiovascular death, myocardial infarction, or stroke in patients presenting with acute myocardial infarction?
Odds Ratio: 2.787 (95% CI 1.091–7.12)
Absolute Event Rate: 15.6% vs 7.4%
p-value: p=0.032
Prediabetes, defined by HbA1c levels, is an independent predictor of adverse cardiovascular events in patients presenting with acute myocardial infarction.
Prediabetes may identify higher post-AMI event risk for closer monitoring; observational data leave open whether intervention alters outcomes.
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Karaaslan et al. (2021) conducted a cohort in Acute myocardial infarction (n=332). Prediabetes (HbA1c 5.7-6.4%) vs. Non-diabetic (HbA1c <5.7%) was evaluated on Composite of cardiovascular death, myocardial infarction, or stroke (OR 2.787, 95% CI 1.091-7.120, p=0.032). Prediabetes significantly increased the risk of the primary composite endpoint of cardiovascular death, myocardial infarction, or stroke compared to normoglycemia in patients with acute myocardial infarction (OR 2.787).
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