Key result
Diabetes linked to ~52% higher 1-year mortality following acute myocardial infarction.
Why the study?
Does concomitant diabetes increase mortality and impact the use of guideline-directed therapies in patients hospitalized with acute myocardial infarction?
Cohort (n=21,094)
Yes
Does concomitant diabetes increase mortality and impact the use of guideline-directed therapies in patients hospitalized with acute myocardial infarction?
Patients with diabetes presenting with acute myocardial infarction represent a high-risk population that continues to suffer from lower utilization of guideline-directed therapies and significantly higher mortality.
Answers are grounded in this paper and cite their sources.
Diabetes linked to care gaps and higher post-AMI mortality; leaves open whether closing disparities improves outcomes in trials.
Background Diabetes is associated with increased risk of acute myocardial infarction (AMI). The demographic trends, clinical presentation, management, and outcomes of patients with diabetes who are hospitalized with AMI have not been recently reported. Methods and Results The ARIC (Atherosclerosis Risk in Communities) study conducted hospital surveillance of AMI in 4 US communities. AMI was classified by physician review using a validated algorithm. Medications and procedures were abstracted from the medical record. From 2000 to 2014, 21 094 weighted hospitalizations for AMI were sampled. The prevalence of diabetes steadily increased, from 35% to 41% to 43% ( P ‐trend<0.0001) across 2000 to 2004, 2005 to 2009, and 2010 to 2014, respectively. Patients with diabetes were older (61 versus 59 years of age), more often Black (44% versus 31%), and more commonly women (42% versus 34%). The burden of cardiovascular comorbidities was higher with diabetes and increased temporally. Patients with diabetes less often presented with ST‐segment elevation (9% versus 17%) or acute chest pain (72% versus 80%), and had higher mean GRACE (Global Registry of Acute Coronary Syndrome) score (123 versus 109), Thrombolysis in Myocardial Ischemia (TIMI) score (4.3 versus 4.0), and Killip class (1.9 versus 1.5). Patients with diabetes had a lower adjusted probability of receiving aspirin (relative probability, 0.95 [95% CI, 0.91–0.99]), nonaspirin antiplatelets (0.93 [95% CI, 0.86–0.99]), coronary angiography (0.85 [95% CI, 0.78–0.92]), and coronary revascularization (0.85 [95% CI, 0.76–0.92]). Diabetes was associated with a 52% higher hazard of all‐cause 1‐year mortality (hazard ratio, 1.52 [95% CI, 1.23–1.89]). Conclusions Diabetes is associated with higher risk of death in patients hospitalized with AMI, highlighting the need for adherence to evidence‐based therapies in this high‐risk population.
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Jain et al. (2023) conducted a cohort in Acute Myocardial Infarction (n=21,094). Diabetes vs. No diabetes was evaluated on All-cause 1-year mortality (HR 1.52, 95% CI 1.23-1.89, p=<0.0001). In patients hospitalized with acute myocardial infarction, diabetes was associated with lower utilization of guideline-directed therapies and a 52% higher hazard of 1-year all-cause mortality.
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