June 13, 2018NeurologyOpen Access

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy

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Authors

AKAndrés M. KannerUniversity of Miami EAEric AshmanAmerican Academy of Neurology DGDavid GlossEpilepsy Foundation

Discussion

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Implication

Practice guideline demonstrates reduced seizure frequency with newer antiepileptic drugs in treatment-resistant epilepsy, highlighting drug selection tailored to syndrome type and patient age.

Key Points

Immediate-release pregabalin and perampanel effectively reduce seizure frequency in focal epilepsy, with rufinamide established as effective adjunctive therapy for Lennox-Gastaut syndrome.
Forty-two articles provided comparative evidence across drug classes, validating specific antiepileptic drugs for focal epilepsy and childhood tonic-clonic seizures.
Practice guideline update using established criteria reviewed literature on treatment-resistant epilepsy, linking recommendations directly to therapeutic evidence strength.
Supports individualized selection of antiepileptic drugs for treatment-resistant epilepsy, while emphasizing patient age, drug tolerability, and syndromic classification.

Cite This Study

Kanner et al. (2018) studied this question.

synapsesocial.com/papers/6a98e785dea2d226f518ea04 https://doi.org/10.1212/wnl.0000000000005756

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Implication

Practice guideline demonstrates reduced seizure frequency with newer antiepileptic drugs in treatment-resistant epilepsy, highlighting drug selection tailored to syndrome type and patient age.

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy

Discussion

Member takes

Implication

Key Points

Cite This Study

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy

Discussion

Member takes

Implication

Key Points

Cite This Study

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