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November 21, 2024Open Access

Immune priming in the insect gut: a dynamic response revealed by ultrastructural and transcriptomic changes

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Authors

MBMoritz BaurNSNora K. E. SchulzLGLilo Greune

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Overview

Laboratory study reveals gut damage triggers innate immune priming in beetle larvae, indicating stress responses prepare tissues for subsequent bacterial infection.

Key Points

  • To determine the structural and transcriptional mechanisms governing oral immune priming in the larval gut of Tribolium castaneum challenged with Bacillus thuringiensis tenebrionis.
  • Orally primed Tribolium castaneum larvae using Bacillus thuringiensis tenebrionis culture supernatants containing virulence factors prior to secondary challenge with infectious spores.
  • Evaluated gut cellular damage and dynamic structural responses over time using transmission electron microscopy.
  • Profiled temporal transcriptomic changes and immune gene expression in primed gut tissues using RNA sequencing.
  • Exposure to pathogen supernatants caused physical gut damage, inducing an early physiological stress response and the targeted upregulation of immune genes.
  • The initial stress response attenuated over time while retaining tissue-level readiness to upregulate virulence-interfering defense genes upon subsequent exposure to infectious spores.

Cite This Study

Baur et al. (2024) studied this question.

synapsesocial.com/papers/6a98e95e19c7e0464f272eeahttps://doi.org/10.1101/2024.11.21.624623
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