Key result
Among older women receiving radiotherapy for breast cancer, left-sided tumors increased the risk of incident cardiovascular disease compared to right-sided tumors (HR 1.53; 95% CI 1.06-2.21).
Why the study?
Does adjuvant radiotherapy and tumor laterality affect the risk of incident cardiovascular disease in older women with stage I and II breast cancer?
Cohort (n=806)
Yes
Does adjuvant radiotherapy and tumor laterality affect the risk of incident cardiovascular disease in older women with stage I and II breast cancer?
Hazard Ratio: 1.53 (95% CI 1.06–2.21)
In older breast cancer survivors, adjuvant radiotherapy for left-sided tumors is associated with a significantly higher long-term risk of cardiovascular disease compared to right-sided tumors.
No takes yet. Share an insight, caveat, or question.
May warrant enhanced cardiac monitoring after left-sided breast radiotherapy; leaves open whether modern techniques mitigate risk in prospective studies.
Haque et al. (2011) conducted a cohort in Stage I and II breast cancer (n=806). Radiotherapy vs. No radiotherapy (full cohort) / Right-sided tumors (RT-exposed group) was evaluated on Incident cardiovascular disease (CVD) (HR 1.53, 95% CI 1.06-2.21). Among older women receiving radiotherapy for breast cancer, left-sided tumors increased the risk of incident cardiovascular disease compared to right-sided tumors (HR 1.53; 95% CI 1.06-2.21).
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