Key result
Valvular endothelial cells in tricuspid aortic valve stenosis showed gene expression alterations specifically in the fibrosa, whereas bicuspid aortic valve stenosis exhibited pathological changes on both sides of the leaflets.
Why the study?
Given prominent pathogenetic and clinical differences between tAVS and bAVS, the study evaluated whether valvular endothelial cell gene expression patterns differ between these conditions.
Gene expression profiling of valvular endothelial cells may elucidate the distinct pathophysiological mechanisms underlying tricuspid versus bicuspid aortic valve stenosis.
ricuspid aortic valve stenosis (tAVS) is a common disease in the elderly.It is characterized by inflammation, fibrosis, and calcification of the valve leaflets leading to impaired valve opening and inadequate blood flow.In contrast to tAVS, bicuspid aortic valve stenosis (bAVS) has a genetic basis, presents earlier in life, and progresses more rapidly, requiring earlier medical intervention; all these points suggest a different pathophysiology than in tAVS.Recent evidence suggests that altered endothelial cell biology contributes to disease development in calcified aortic disease in general 1 and bAVS in particular, 1,2 All sequencing data sets reported in this manuscript are deposited in the Short Read Archive at the National Center for Biotechnology Information under the BioProject ID PRJNA1251826.Additional data that support the findings of this study are available from the corresponding author upon request.The study was approved by the local ethics committee and subjects gave informed consent.Given the prominent pathogenetic and clinical differences between tAVS and bAVS, we analyzed gene expression patterns of valvular endothelial cells (VECs) from fibrosa (aortic side of the leaflet) and ventricularis (ventricular side of the leaflet) in these 2 patient cohorts in humans.
No takes yet. Share an insight, caveat, or question.
Brandtner et al. (2025) conducted a letter in Tricuspid and Bicuspid Aortic Valve Stenosis. Bicuspid aortic valve stenosis vs. Tricuspid aortic valve stenosis was evaluated on Differentially expressed genes in valvular endothelial cells. Valvular endothelial cells in tricuspid aortic valve stenosis showed gene expression alterations specifically in the fibrosa, whereas bicuspid aortic valve stenosis exhibited pathological changes on both sides of the leaflets.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: