Key result
Bicuspid aortic valves are linked to 52 differentially regulated aortic convexity proteins versus tricuspid valves.
Why the study?
The intracellular proteome differences in ascending aortas between patients with stenotic bicuspid and tricuspid aortic valves were not fully characterized, limiting understanding of BAV-specific aortopathy mechanisms.
Are there differences in the intracellular proteome of ascending aortas between patients with stenotic bicuspid and tricuspid aortic valves?
Population
52 patients with stenotic aortic valves (26 BAV, 26 TAV) undergoing valve replacement
Comparison
Ascending aorta proteome in BAV versus TAV patients at convexity and concavity
Design
Observational proteomic analysis with 2D fluorescence difference in-gel electrophoresis and mass spectrometry
Authors
Loading...
BAV aortas exhibit more proteomic changes at convexity preaneurysmally; leaves open causal mechanisms and clinical relevance.
Observational (n=52)
Are there differences in the intracellular proteome of ascending aortas between patients with stenotic bicuspid and tricuspid aortic valves?
At a preaneurysmal stage, ascending aortas with bicuspid aortic valves show more protein expression changes at the convexity than at the concavity compared to tricuspid aortic valves, suggesting BAV-specific pathogenetic mechanisms of aortopathy.
Forte et al. (2019) conducted an observational in Stenotic bicuspid and tricuspid aortic valves (n=52). Bicuspid aortic valve vs. Tricuspid aortic valve was evaluated on Differentially regulated protein spots in ascending aorta. Compared to tricuspid aortic valves, non-aneurysmal ascending aortas from patients with bicuspid aortic valves showed 52 differentially regulated protein spots at the convexity and 10 at the concavity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: