Key result
Bicuspid aortic valve in neonatal coarctation patients was associated with 34 differentially expressed proteins and significantly enriched elastin fibre formation (p = 1.12 × 10−4).
Why the study?
Congenital BAV causes hemodynamic changes that may trigger molecular remodelling in coarctation of the aorta, but associated proteomic and phosphoproteomic changes in neonates had not been investigated.
Does the presence of a bicuspid aortic valve alter the aortic protein expression profile in neonatal coarctation patients compared to a tricuspid aortic valve?
Population
23 neonates with coarctation of the aorta aged 4-22 days
Comparison
BAV (n = 10) vs TAV (n = 13)
Design
Comparative tissue analysis study
Authors
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BAV-coarctation neonates show distinct proteomic remodeling; leaves open whether these proteins predict outcomes or warrant tailored surveillance.
Observational (n=23)
Does the presence of a bicuspid aortic valve alter the aortic protein expression profile in neonatal coarctation patients compared to a tricuspid aortic valve?
Neonatal coarctation patients with bicuspid aortic valves exhibit altered aortic proteomic profiles and increased elastin content compared to those with tricuspid valves, suggesting distinct molecular remodeling.
Skeffington et al. (2019) conducted an observational in Coarctation of the aorta (n=23). Bicuspid aortic valve vs. Normal tricuspid aortic valve was evaluated on Differentially expressed proteins and phosphoproteins. Bicuspid aortic valve in neonatal coarctation patients was associated with 34 differentially expressed proteins and significantly enriched elastin fibre formation (p = 1.12 × 10−4).
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