Key result
In infants with ventricular septal defect, 150 proteins and 19 phosphorylation sites showed significantly lower expression in the right atria compared to the right ventricle.
Why the study?
Does the proteome differ between the right atria and right ventricles in infants with congenital ventricular septal defect?
Population
5 infants with congenital ventricular septal defect undergoing reparative cardiac surgery.
Comparison
Right ventricle (RV) tissue analysis vs Right atrial (RA) tissue analysis
Design
Cross-sectional
Authors
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Highlights chamber-specific proteomic differences in infant VSD; hypothesis-generating and requires prospective validation before clinical relevance.
Cross-Sectional (n=5)
Does the proteome differ between the right atria and right ventricles in infants with congenital ventricular septal defect?
Significant proteomic differences exist between the right atria and right ventricles in infants with VSD, suggesting caution when using atrial tissue as a surrogate for ventricular remodeling.
Bond et al. (2018) conducted a cross-sectional in Congenital ventricular septal defect (VSD) (n=5). Right ventricle (RV) tissue vs. Right atrial (RA) tissue was evaluated on Differences in protein expression between RV and RA. In infants with ventricular septal defect, 150 proteins and 19 phosphorylation sites showed significantly lower expression in the right atria compared to the right ventricle.
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