Key result
Proteomic analysis of aortic valve interstitial cells identified 39 differentially expressed proteins in patients with aortic stenosis compared to normal valves.
Why the study?
The mechanisms underlying aortic stenosis pathogenesis remain unclear, limiting advancements in clinical treatment and biomedical research.
Population
AS patients with TAV (n=10) and BAV (n=10), plus normal aortic valve donors (n=11)
Comparison
VICs from TAV-AS and BAV-AS vs normal aortic valves
Design
Quantitative proteomic analysis study
Authors
Loading...
Hypothesis-generating for aortic stenosis mechanisms; leaves open validation as biomarkers or targets before clinical relevance.
Observational (n=31)
Proteomic analysis of aortic valve interstitial cells identified specific differentially expressed proteins in tricuspid and bicuspid aortic stenosis, providing potential molecular targets for understanding pathogenesis and therapeutic development.
Song et al. (2025) conducted an observational in Aortic stenosis (n=31). Aortic stenosis (TAV and BAV) vs. Normal aortic valves was evaluated on Differentially expressed proteins (DEPs) in aortic valve interstitial cells. Proteomic analysis of aortic valve interstitial cells identified 39 differentially expressed proteins in patients with aortic stenosis compared to normal valves.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: