Key result
In pediatric patients with coarctation of the aorta, a bicuspid aortic valve was associated with significant differential expression of 40 proteins and 6 phosphoproteins compared to a tricuspid valve.
Why the study?
Neonatal structural differences between coarctation of the aorta with bicuspid versus tricuspid aortic valve likely change with growth, but proteomic differences in children older than one month remain unclear.
Does the presence of a bicuspid aortic valve alter the proteomic profile of coarcted aortic tissue in children older than one month compared to a tricuspid aortic valve?
Population
10 children older than one month with coarctation of the aorta
Comparison
Bicuspid aortic valve (n=6) vs tricuspid aortic valve (n=4)
Design
Proteomic and phosphoproteomic tissue analysis
Authors
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Supports BAV-specific strategies in CoA repair; extends neonatal proteomic differences to children >1 month.
Cross-Sectional (n=10)
No
Does the presence of a bicuspid aortic valve alter the proteomic profile of coarcted aortic tissue in children older than one month compared to a tricuspid aortic valve?
Children older than one month with coarctation of the aorta and a bicuspid aortic valve exhibit altered proteomic profiles indicative of inflammation, apoptosis, and oxidative stress compared to those with a tricuspid aortic valve.
Skeffington et al. (2020) conducted a cross-sectional in Coarctation of the aorta (n=10). Bicuspid aortic valve vs. Tricuspid aortic valve was evaluated on Differentially expressed proteins and phosphoproteins in coarcted aortic tissue. In pediatric patients with coarctation of the aorta, a bicuspid aortic valve was associated with significant differential expression of 40 proteins and 6 phosphoproteins compared to a tricuspid valve.
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