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A study was made of the effectiveness of intra-articular administration of 6-methylprednisolone acetate, hydrocortisone tertiary-butylacetate and prednisolone tertiary-butylacetate.The 6-methylprednisolone acetate was more effective than prednisolone tertiary-butylacetate or hydrocortisone tertiary-butylacetate in five cases; it was less effective than these two steroids in three cases, and equally effective in 30 cases.In almost all instances the three steroids had a pronounced local anti-inflammatory effect on the rheumatoid process, with little difference in the degree of relief produced by each of the steroids.
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Bilka et al. (1959) studied this question.
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