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December 15, 1999Journal of Biomedical Materials Research

Bone healing and mineralization, implant corrosion, and trace metals after nickel-titanium shape memory metal intramedullary fixation

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Population

40 rats with femoral osteotomies

Comparison

NiTi shape memory alloy intramedullary nails vs Stainless steel (StSt) intramedullary nails

Design

Preclinical

Follow-up

up to 60 weeks (assessed at 2, 4, 8, 12, 26, and 60 weeks)

Authors

JRJ. Ryh�nenOulu University HospitalMKMatti KallioinenOulu University HospitalWSWilly SerloOulu University Hospital

Discussion

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Overview

NiTi may accelerate early bone union without nickel accumulation in rats; leaves open human translation pending clinical trials.

Structured PICO

P
Population
40 rats with femoral osteotomies
I
Intervention
NiTi (nickel-titanium) shape memory alloy intramedullary nails
C
Comparator
Stainless steel (StSt) intramedullary nails
O
Outcome
Bone healing (assessed by radiographs, pQCT, and histology), implant corrosion, and trace metal concentrations in organssurrogate

NiTi shape memory alloy demonstrates good biocompatibility and bone healing properties in a rat model, supporting its potential for intramedullary orthopedic use.

Cite This Study

Ryh�nen et al. (1999) studied this question.

synapsesocial.com/papers/6a98ea177384e28de71feed6https://doi.org/10.1002/(sici)1097-4636(19991215)47:4<472::aid-jbm3>3.0.co;2-z
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