Fetal development in the rat was severely affected by a 36-hour period of pteroylglutamic acid deficiency when instituted early in the second week of pregnancy. The incidence of fetal death or abnormality was higher when the vitamin-deficient diet was started on the 8th day of pregnancy than on the 7 th day but decreased rapidly thereafter with increasing fetal age.
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Nelson et al. (1956) studied this question.