Key result
Sutureless aortic valve replacement was associated with higher rates of new-onset LBBB (16.7% vs 2.3%, P<0.001) and pacemaker implantation (6.8% vs 1.6%, P=0.001) compared to conventional AVR.
Why the study?
Postoperative LBBB and PPM implantation have emerged as frequent complications of sutureless aortic valve prostheses, prompting an evaluation of their incidence and impact on survival compared to stented bioprostheses.
Does sutureless aortic valve replacement increase the risk of conduction disorders and affect survival compared to conventional stented bioprostheses in patients undergoing surgical AVR?
Cohort (n=987)
Does sutureless aortic valve replacement increase the risk of conduction disorders and affect survival compared to conventional stented bioprostheses in patients undergoing surgical AVR?
Absolute Event Rate: 16.7% vs 2.3%
p-value: p=<0.001
Sutureless aortic valve replacement significantly increases the risk of new-onset LBBB and permanent pacemaker implantation compared to conventional AVR, though these conduction disorders do not appear to negatively impact mid-term survival.
OBJECTIVES: Sutureless and rapid-deployment aortic valve prostheses are frequently used for the treatment of aortic stenosis. However, postoperative left bundle branch block (LBBB) and permanent pacemaker (PPM) implantation have emerged as frequent complications. The aim of this study was to compare the incidence of new-onset LBBB and PPM implantation after sutureless aortic valve replacement (sAVR) with stented bioprostheses, and the impact on postoperative survival. METHODS: Patients undergoing isolated surgical aortic valve replacement (AVR) or concomitant AVR with coronary artery bypass surgery between January 2010 and July 2017 were included in the study. Two groups were defined: sAVR and conventional AVR (cAVR). The findings of preoperative electrocardiograms were compared with postoperative electrocardiogram findings for both groups. The incidence of new-onset LBBB and the requirement for PPM implantation were recorded. The effect of these conduction disorders on late survival was analysed. RESULTS: A total of 987 patients were analysed, consisting of 132 sAVR and 855 cAVR patients. The sAVR group had an increased incidence of new-onset LBBB compared to the cAVR group (16.7% vs 2.3%, P < 0.001). A significantly higher rate of postoperative PPM implantation was found for sAVR patients compared to cAVR (6.8% vs 1.6%, P = 0.001). The multivariate Cox analysis revealed that neither postoperative new-onset LBBB nor PPM implantation was associated with increased mortality (hazard ratio 1.73, 95% confidence interval 0.74-4.03, P = 0.204). CONCLUSIONS: sAVR is associated with an increased risk of new-onset LBBB and PPM requirement compared to cAVR. In this population, postoperative conduction disorders did not affect the mid-term survival.
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Lam et al. (2018) conducted a cohort in Aortic stenosis (n=987). Sutureless aortic valve replacement (sAVR) vs. Conventional aortic valve replacement (cAVR) was evaluated on New-onset left bundle branch block (LBBB) (p=<0.001). Sutureless aortic valve replacement was associated with higher rates of new-onset LBBB (16.7% vs 2.3%, P<0.001) and pacemaker implantation (6.8% vs 1.6%, P=0.001) compared to conventional AVR.
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