Why the study?
Does the renin-angiotensin system mediate coronary arteriolar constriction during experimental myocardial ischemia, and can it be reversed by captopril?
Population
Experimental animal model of myocardial ischemia with cannulated and perfused left anterior descending…
Comparison
Adenosine, indomethacin, saralasin, and captopril vs Control animals (n=18)
Design
Preclinical
Follow-up
Up to 6 hours of coronary occlusion
Authors
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ACE inhibition may limit experimental infarct size; leaves open translation to human ischemia pending clinical trials.
Does the renin-angiotensin system mediate coronary arteriolar constriction during experimental myocardial ischemia, and can it be reversed by captopril?
The renin-angiotensin system is activated by myocardial ischemia and exerts a coronary constrictive tone, which can be beneficially reversed by ACE inhibition with captopril.
Georg Ertl (1987) studied this question.
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