Key result
Moderate ischemia drives a positive feedback cycle reducing both ventricular function and coronary blood flow.
Population
Ischaemic canine hearts and isolated guinea pig hearts
Design
Preclinical
Follow-up
3 hours
Authors
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Should not change ischemic heart disease management; leaves open whether metabolic vasodilator depletion drives progressive hypoperfusion in patients.
The study demonstrates that progressive vasomotor changes in ischaemic myocardium are likely due to a decreasing release of metabolic vasodilators, creating a positive feedback cycle that reduces ventricular function and blood flow.
Gorman et al. (1985) studied Ischaemic myocardium. Coronary artery stenosis was evaluated on Vascular resistance and vasodilator reserve. During moderate ischaemia, myocardial function and blood flow are linked in a positive feedback cycle which promotes reduced ventricular function and coronary blood flow.
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