Key result
In a computational model of paced cardiac tissue, the size of the paced region critically determines whether conduction blocks are stationary or traveling, revealing a novel arrhythmogenic mechanism.
Population
Computational models of paced cardiac tissue using a modified Luo-Rudy electrophysiological model and a…
Design
Preclinical
Authors
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May inform pacing protocols to mitigate arrhythmia risk; leaves open whether this mechanism translates to human hearts.
The size of the paced region in cardiac tissue critically determines the dynamics of conduction blocks, which can lead to a novel mechanism for arrhythmogenesis and reentry.
Henry et al. (2005) studied Cardiac arrhythmias. Pacing region size variation in simulated cardiac tissue was evaluated on Dynamics of conduction blocks. In a computational model of paced cardiac tissue, the size of the paced region critically determines whether conduction blocks are stationary or traveling, revealing a novel arrhythmogenic mechanism.
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