Key result
Recurrent oral ulceration caused by HSV-1 can cause significant morbidity, with delayed healing in immunocompromised patients, warranting consideration of systemic antiviral treatment.
Recurrent oral ulceration caused by HSV-1 can cause significant morbidity, with delayed healing and more debilitating effects in immunocompromised patients, sometimes indicating systemic antiviral treatment.
UNLABELLED: Human herpes simplex 1 virus (HSV-1) is a DNA virus that has the ability to lie latent and be subsequently re-activated at any point during a patient's life. In the immunocompetent patient, resolution of clinical signs and symptoms usually occurs spontaneously after 14 days. In the immunocompromised patient, healing is often delayed and the effects are much more debilitating. Indications for therapeutic regimes of systemic antiviral treatment are discussed. CLINICAL RELEVANCE: Recurrent oral ulceration caused by HSV-1 may be seen by the general dental practitioner and can cause significant morbidity.
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Westley et al. (2011) conducted a review in Recurrent intra-oral herpes simplex 1 infection. Systemic antiviral treatment was evaluated. Recurrent oral ulceration caused by HSV-1 can cause significant morbidity, with delayed healing in immunocompromised patients, warranting consideration of systemic antiviral treatment.
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