Key result
High-normal albuminuria was independently associated with an increased carotid plaque count (PR 1.06) and greater intima-media thickness in non-diabetic men with normal kidney function.
Why the study?
Low-grade albuminuria is considered a predictor of cardiovascular mortality, but its relationship with subclinical atherosclerosis in non-diabetic men with eGFR ≥60 mL/min/1.73 m2 was investigated.
Does high-normal albuminuria correlate with subclinical atherosclerosis in non-diabetic men with eGFR ≥60 mL/min/1.73 m2?
Cross-Sectional (n=1,756)
No
Does high-normal albuminuria correlate with subclinical atherosclerosis in non-diabetic men with eGFR ≥60 mL/min/1.73 m2?
Relative Risk: 1.06 (95% CI 1.01–1.14)
Absolute Event Rate: 63.7% vs 56.9%
p-value: p=0.034
High-normal albuminuria is independently associated with subclinical atherosclerosis in non-diabetic men with normal renal function, suggesting it may serve as an early marker for cardiovascular risk.
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High-normal albuminuria may flag subclinical atherosclerosis in non-diabetic men; leaves open causal and prognostic implications pending prospective data.
Kimura et al. (2019) conducted a cross-sectional in Subclinical atherosclerosis (n=1,756). High-normal albuminuria (UACR 10.0-29.8 mg/g) vs. Low-normal albuminuria (UACR <10.0 mg/g) was evaluated on Increased carotid plaque count (PR 1.06, 95% CI 1.01-1.14, p=0.034). High-normal albuminuria was independently associated with an increased carotid plaque count (PR 1.06) and greater intima-media thickness in non-diabetic men with normal kidney function.
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