Key result
End-stage renal disease patients on peritoneal dialysis had greater carotid intima media thickness (0.60 vs 0.54 mm, p<0.001) and lower flow-mediated dilatation (0.15 vs 0.21 cm, p=0.02) than controls.
Why the study?
Does end-stage renal disease on peritoneal dialysis associate with worse carotid intima media thickness and flow-mediated dilatation compared to diabetic and hypertensive patients with normal renal function?
Cross-Sectional (n=124)
Does end-stage renal disease on peritoneal dialysis associate with worse carotid intima media thickness and flow-mediated dilatation compared to diabetic and hypertensive patients with normal renal function?
Absolute Event Rate: 0.6% vs 0.54%
p-value: p=<0.001
End-stage renal disease patients on peritoneal dialysis have significantly greater carotid intima media thickness and lower flow-mediated dilatation compared to diabetic and hypertensive patients with normal renal function, indicating worse atherosclerosis and endothelial dysfunction.
End-stage renal disease on peritoneal dialysis was associated with worse vascular markers; hypothesis-generating and should not change practice.
OBJECTIVES: We compared carotid intima media thickness (CIMT) and flow-mediated dilatation (FMD) between cases [end-stage renal disease patients (diabetic and nondiabetic) on peritoneal dialysis (PD)] and controls (diabetic and hypertensive patients with normal renal function) with the objective of identifying risk factors predicting atherosclerosis. METHODS: This cross-sectional study involved 124 subjects (62 cases, 62 controls). In both the case and control populations, we used B-mode ultrasonography to study CIMT and endothelium-dependent FMD, according to American College of Cardiology guidelines on brachial artery measurement. Pearson correlation was used to evaluate the correlation between CIMT and other variables. RESULTS: Compared with controls, cases had significantly higher systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, triglycerides, serum uric acid, inorganic phosphate, C-reactive protein, and parathyroid hormone, and significantly lower hemoglobin, calcium, and high-density lipoprotein. Compared with controls, cases showed significantly greater CIMT (0.60 +/- 0.08 mm vs 0.54 +/- 0.03 mm, p < 0.001) and significantly lower FMD (0.15 +/- 0.08 cm vs 0.21 +/- 0.04 cm, p = 0.02). Among cases, patients with diabetes had significantly greater CIMT (0.62 +/- 0.08 mm vs 0.58 +/- 0.07 mm, p = 0.05) than did patients without diabetes; FMD was similar in diabetic and nondiabetic patients on continuous ambulatory PD (0.16 +/- 0.03 cm vs 0.18 +/- 0.03 cm, p = 0.20). CONCLUSIONS: Compared with controls, cases had significantly higher CIMT and lower FMD. Cases with diabetes had significantly higher CIMT than did cases without diabetes, but FMD was similar in diabetic and nondiabetic cases. Serum inorganic phosphate is an independent risk factor for atherosclerosis and was significantly correlated with CIMT. The noninvasive CIMT and FMD tests can be used to monitor atherosclerosis and endothelial dysfunction.
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Prasad et al. (2009) conducted a cross-sectional in End-stage renal disease on peritoneal dialysis (n=124). End-stage renal disease on peritoneal dialysis vs. Diabetic and hypertensive patients with normal renal function was evaluated on Carotid intima media thickness (CIMT) (p=<0.001). End-stage renal disease patients on peritoneal dialysis had greater carotid intima media thickness (0.60 vs 0.54 mm, p<0.001) and lower flow-mediated dilatation (0.15 vs 0.21 cm, p=0.02) than controls.
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