Key result
Baseline CRP levels in the top tertile (>5.4 mg/L) were associated with a significantly increased hazard of incident ischemic stroke compared to the bottom tertile (HR 2.16; 95% CI 1.32-3.53).
Why the study?
Does elevated C-reactive protein predict incident ischemic stroke in patients with stable coronary heart disease?
Population
2979 patients with stable coronary heart disease included in a controlled clinical trial
Comparison
High baseline C-reactive protein levels vs Low baseline C-reactive protein levels
Design
Cohort
Follow-up
mean 6.2 years
Authors
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Elevated CRP may aid stroke risk stratification in stable CHD; hypothesis-generating and should not yet change practice.
Cohort (n=2,979)
Does elevated C-reactive protein predict incident ischemic stroke in patients with stable coronary heart disease?
Hazard Ratio: 2.16 (95% CI 1.32–3.53)
Absolute Event Rate: 10.5% vs 4.1%
p-value: p=<0.001
Elevated CRP levels independently predict an increased risk of incident ischemic stroke in patients with stable coronary heart disease.
Tanné et al. (2006) conducted a cohort in stable coronary heart disease (n=2,979). C-reactive protein (CRP) levels vs. Lowest tertile (<2.3 mg/L) was evaluated on incident ischemic stroke (HR 2.16, 95% CI 1.32 to 3.53, p=<0.001). Baseline CRP levels in the top tertile (>5.4 mg/L) were associated with a significantly increased hazard of incident ischemic stroke compared to the bottom tertile (HR 2.16; 95% CI 1.32-3.53).
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