Key result
Carriers of the LDL-R defective gene with asymptomatic severe hypercholesterolemia had significantly higher mean carotid intima-media thickness compared to non-carriers (1.07 mm vs 0.93 mm, p<0.05).
Why the study?
Does being a carrier of the LDL-R defective gene increase carotid intima-media thickness in asymptomatic patients with severe hypercholesterolemia compared to non-carriers?
Cross-Sectional (n=60)
No
Does being a carrier of the LDL-R defective gene increase carotid intima-media thickness in asymptomatic patients with severe hypercholesterolemia compared to non-carriers?
Asymptomatic patients with severe hypercholesterolemia who carry LDL-R defective genes have significantly higher carotid intima-media thickness than non-carriers, suggesting a higher atherosclerotic burden despite similar lipid profiles.
May signal higher atherosclerotic burden in LDL-R carriers; hypothesis-generating for genetic risk stratification in severe hypercholesterolemia.
The data on the examination of early vascular alterations in carriers of molecular defects of the LDL-R in comparison to non-carriers with severe hypercholesterolemia are controversial. Aim: To examine the difference between patients with severe hypercholesterolemia, who are carriers and non-carriers of LDL-R defective gene, with respect to their structural (intima-media thickness of carotid artery) characteristics of arterial wall. A total of 60 hypercholesterolemic patients were enrolled. Biochemistry parameters were examined by routine methods. Determination of intima-media thickness of common carotid artery was performed with Hewlett Packard Sonos 5 500, using automated computer software MedicaSoft. IMT.lab. Results: There was no significant difference between the groups with respect to total cholesterol, LDL, HDL, triglycerides. We were founded a significantly higher carotid IMT in the carriers versus non-carriers. This significant difference was confirmed after adjustment for age and gender. Conclusion: Our data demonstrate that carriers of the LDL-R defective gene have a higher carotid IMT than non-carriers, whereas no difference between the groups was found with respect to the level of lipid parameters.
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Lyudmila Vladimirova‐Kitova (2011) conducted a cross-sectional in Asymptomatic severe hypercholesterolemia (n=60). LDL-R defective gene vs. Non-carriers of LDL-R defective gene was evaluated on Mean intima-media thickness (IMT) of the common carotid artery (p=<0.05). Carriers of the LDL-R defective gene with asymptomatic severe hypercholesterolemia had significantly higher mean carotid intima-media thickness compared to non-carriers (1.07 mm vs 0.93 mm, p<0.05).
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