Increased Carotid Artery Intima-Media Thickness in Subjects With Primary Hypoalphalipoproteinemia
Why the study?
Is primary hypoalphalipoproteinemia or hyperalphalipoproteinemia associated with increased carotid intima-media thickness compared to average HDL-C levels?
Population
55 subjects with primary hypoalphalipoproteinemia or hyperalphalipoproteinemia, 55 control subjects with…
Comparison
Primary hypoalphalipoproteinemia or… vs Control subjects with average HDL-C levels
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Low HDL-C was associated with greater carotid IMT; leaves open whether HDL-C modification alters atherosclerosis progression.
Structured PICO
Is primary hypoalphalipoproteinemia or hyperalphalipoproteinemia associated with increased carotid intima-media thickness compared to average HDL-C levels?
P
Population
55 subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP), 55 control subjects with average HDL-C levels (matched for sex, age, and plasma cholesterol), and a separate cohort of 559 hyperlipidemic subjects.
I
Intervention
Primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP)
C
Comparator
Control subjects with average HDL-C levels
O
Outcome
Average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segmentssurrogate
Low HDL-C is associated with significant pre-intrusive atherosclerosis as measured by carotid IMT, whereas high HDL-C does not further reduce arterial wall thickening compared to average levels.
Cite This Study
Baldassarre et al. (2002) studied this question.