Blockers, anchors, and reporters: A solid-phase method for the synthesis of lipidated peptides (see scheme) relies on the base-labile Fmoc group to block the N-terminus, an oxidation-labile hydrazide linker for anchoring to the solid support, and lipidated amino acid building blocks incorporating labels or photoactivatable groups.
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Kragol et al. (2004) studied this question.
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