Synthesis and Anticancer Evaluation of 2-{4-[5-(5-Substituted arylpyrimidin-2-yl)-1H-pyrazol-3-yl]-phenyl}thiazolo[4,5-b]pyridine Derivatives

In the present study a new series of 2-{4-[5-(5-substituted arylpyrimidin-2-yl)-1 H -pyrazol-3-yl] phenyl}thiazolo[4,5- b ]pyridine derivatives (11a–11j) are synthesized and tested for their anticancer activity against four human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) by the MTT assay. Among synthesized compounds, 11b, 11c, 11d, 11g , and 11j exhibit activity higher than the standard drug.