What question did this study set out to answer?

To establish a model-free mathematical framework that links phenotypic variations among individual cell lineages to macroscopic population growth rates using fitness landscape cumulants.

October 28, 2022eLifeOpen Access

A unified framework for measuring selection on cellular lineages and traits

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Authors

SYShunpei YamauchiThe University of Tokyo TNTakashi NozoeUniversal University ROReiko OkuraThe University of Tokyo

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Implication

Theoretical study demonstrates the impact of fitness heterogeneity on population growth across cellular lineages, highlighting cumulant contributions during regrowth from growth arrest.

Key Points

To establish a model-free mathematical framework that links phenotypic variations among individual cell lineages to macroscopic population growth rates using fitness landscape cumulants.
Expanded population growth rate via the cumulants of fitness distributions to assess the distinct contributions of variance, skewness, and higher-order moments.
Introduced a lineage statistics function to evaluate mean lineage fitness and selection strength across chronological and retrospective statistics.
Applied the framework to experimental single-cell tracking datasets spanning bacterial and mammalian cell populations in steady and regrowing states.
Showed that fitness heterogeneity provides measurable growth rate advantages across diverse organisms and environments, with higher-order cumulants contributing significantly during regrowth from growth arrest.
Identified that third and higher-order cumulants remain negligible under constant growth conditions but become prominent drivers during recovery phases.
Demonstrated that natural selection can induce higher fitness variance in retrospective lineage statistics compared to chronological lineage statistics.

Cite This Study

Yamauchi et al. (2022) studied this question.

synapsesocial.com/papers/6a98fcaee8ca4d2af6362d03 https://doi.org/10.7554/elife.72299

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Implication

Theoretical study demonstrates the impact of fitness heterogeneity on population growth across cellular lineages, highlighting cumulant contributions during regrowth from growth arrest.

A unified framework for measuring selection on cellular lineages and traits

Discussion

Member takes

Implication

Key Points

Cite This Study

A unified framework for measuring selection on cellular lineages and traits

Discussion

Member takes

Implication

Key Points

Cite This Study

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