Population
Human and veterinary literature on the role of the vascular endothelial cell in health and disease
Design
Review
Key result
The vascular endothelium is an essential organ system regulating permeability, vascular tone, and coagulation; its dysfunction during disease contributes to thrombosis and multiple organ dysfunction.
Authors
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May inform supportive care in veterinary critical illness; leaves open targeted endothelial therapies pending prospective trials.
This review highlights the essential physiological functions of the vascular endothelium and its pathophysiological role in disease states across species.
Duffy et al. (2004) conducted a review in hypoxic and inflammatory disease states. The vascular endothelium is an essential organ system regulating permeability, vascular tone, and coagulation; its dysfunction during disease contributes to thrombosis and multiple organ dysfunction.
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