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October 16, 2020Behavior Genetics6 citationsOpen Access

The Heritability of Type D Personality by an Extended Twin-Pedigree Analysis in the Netherlands Twin Register

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Population

30,433 participants from the Netherlands Twin Register

Design

Cohort

Key result

Type D personality and its subcomponents are substantially heritable, with broad-sense heritability for the continuous Type D measure estimated at 49%.

Authors

RLRuifang Li‐GaoDBDorret I. BoomsmaEGEco J. C. de Geus

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Overview

Supports genetic research on Type D personality; leaves open clinical utility for cardiovascular risk assessment.

Study Design

Type

Observational (n=30,433)

Structured PICO

P
Population
30,433 late-adolescent and adult twins and their relatives from the Netherlands Twin Register assessed for the heritability of Type D personality.
O
Outcome
Heritability of Type D personality and its negative affectivity (NA) and social inhibition (SI) subcomponents

Type D personality and its subcomponents are highly heritable, with a shared genetic basis for negative affectivity and social inhibition.

Main Result

Effect estimate: 49% (95% CI 47-51)

Limitations

  • The likelihood-ratio test of a variance component does not follow the usual central χ2(1) distribution under the hypothesis that the variance component is zero, which may have inflated p-value estimations.
  • Inability to model the genetic effects of phenotypic assortative mating in the Mendel software.

Cite This Study

Li‐Gao et al. (2020) conducted an observational in Type D personality (n=30,433). Genetic and environmental factors was evaluated on Broad-sense heritability of the continuous Type D personality measure (NAxSI) (49%, 95% CI 47-51). Type D personality and its subcomponents are substantially heritable, with broad-sense heritability for the continuous Type D measure estimated at 49%.

synapsesocial.com/papers/6a99078fb3d4f622baf0d202https://doi.org/10.1007/s10519-020-10023-x
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