Key result
High leisure-time physical activity at baseline predicted significantly higher small arterial compliance after nearly 10 years compared to low activity (mean difference 0.44 ml/mmHg).
Why the study?
The study investigated the association between levels of leisure-time physical activity and vascular stiffness over time in a representative population.
Does high leisure-time physical activity improve vascular elasticity indices in individuals without hypertension?
Observational (n=761)
Does high leisure-time physical activity improve vascular elasticity indices in individuals without hypertension?
High leisure-time physical activity predicts higher small arterial compliance over a nearly 10-year follow-up, suggesting persistent positive effects on vascular elasticity.
Higher LTPA was associated with better small-artery elasticity after ~10 years; leaves open whether increasing activity slows vascular aging in trials.
AIM: We investigated the association between levels of leisure-time physical activity and vascular stiffness in a longitudinal observational study from a representative Swedish population. METHOD: A total of 2816 randomly selected individuals were examined at visit 1 (2002-2005, Men = 1400). After a mean follow-up of 9.7 ± 1.4 years, a representative sample of 1327 of the original participants were re-examined at visit 2. After excluding subjects with hypertension at baseline, 761 participants were included in the longitudinal analyses. Leisure-time physical (LTPA) activity was self-reported and dichotomized as high or low (level 3, 4 and level 1, 2, respectively). Large Arterial Elasticity Index (LAEI) and Small Arterial Elasticity Index (SAEI) were measured using the HDI/Pulse Wave™ CR2000. Multivariable general linear models were used to investigate the differences in changes SAEI and LAEI based on LTPA levels. RESULTS: At visit 1, and after adjustment for possible confounders, participants in the high LTPA group had better small artery elasticity (SAEI) (SAEI in low-level LTPA: 7.89 ± 0.11, SAEI in high-level LTPA: 8.32 ± 0.15, ΔSAEI: 0.42, CI: 0.07-0.78; p = 0.020). SAEI decreased between the two assessments (Visit 1: SAEI 8.01 ± 3.37 ml/mmHg; Δ SAEI: 1.4, CI 1.2-1.6, p < 0.001). Participants with a higher LTPA at visit 1 had significantly better SAEI at visit 2 (ΔSAEI: 0.44, CI 0.03-0.85, p = 0.037). No significant associations were observed between LAEI and LTPA after adjustments. CONCLUSIONS: High LTPA predicted higher small arterial compliance at visit 2 suggesting that positive effects of LTPA on arterial elasticity persists over time.
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Szaló et al. (2021) conducted an observational in Vascular stiffness (n=761). High leisure-time physical activity vs. Low leisure-time physical activity was evaluated on Small Arterial Elasticity Index (SAEI) at visit 2 (MD 0.44, 95% CI 0.03-0.85, p=0.037). High leisure-time physical activity at baseline predicted significantly higher small arterial compliance after nearly 10 years compared to low activity (mean difference 0.44 ml/mmHg).
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