Key result
Myosin Va plays multiple roles in the trafficking of secretory granules, including capture, transport, and late transport events preceding exocytosis.
Myosin Va is implicated in multiple stages of secretory granule trafficking and exocytosis through interactions with proteins involved in regulated protein secretion.
It emerges that myosin Va plays multiple roles in the trafficking of SGs (secretory granules). In addition to a function in the capture and transport of newly formed SGs in the F-actin-rich cortex, myosin Va is implicated in late transport events of these organelles, which precede their exocytosis. Consistent with these roles, interactions of myosin Va with an array of well-known proteins involved in regulated protein secretion have been documented.
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Eichler et al. (2006) reported a review. Myosin Va was evaluated. Myosin Va plays multiple roles in the trafficking of secretory granules, including capture, transport, and late transport events preceding exocytosis.
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