Key result
Myosin Va is involved in multiple successive steps in the development of dense-core vesicles, including membrane remodelling, transport along actin filaments, and regulation of exocytosis.
This review highlights the versatile roles of the motor protein myosin Va in the maturation, transport, and exocytosis of dense-core vesicles.
Myosin Va roles in vesicle trafficking merit targeted cardiac studies; leaves open any clinical relevance or therapeutic targeting.
The motor protein myosin Va is involved in multiple successive steps in the development of dense-core vesicles, such as in the membrane remodelling during their maturation, their transport along actin filaments and the regulation of their exocytosis. In the present paper, we summarize the current knowledge on the roles of myosin Va in the different steps of dense-core vesicle biogenesis and exocytosis, and compare findings obtained from different cell types and experimental systems.
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Kögel et al. (2010) conducted a review in Dense-core vesicle biogenesis and function. Myosin Va was evaluated. Myosin Va is involved in multiple successive steps in the development of dense-core vesicles, including membrane remodelling, transport along actin filaments, and regulation of exocytosis.
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