Key result
Left atrial low-voltage area guided ablation in addition to pulmonary vein isolation is being evaluated for superiority against pulmonary vein isolation alone in a planned trial of 340 patients with persistent atrial fibrillation.
Why the study?
Recurrence rates of AF after PVI are higher in patients with a left atrial low-voltage area, but the efficacy of LVA guided ablation is still unknown.
Does left atrial low-voltage area guided ablation in addition to pulmonary vein isolation reduce the recurrence of atrial fibrillation in patients with persistent atrial fibrillation and low-voltage areas?
Population
340 patients with persistent AF and LVAs undergoing their first catheter ablation
Comparison
LVA guided ablation in addition to PVI vs PVI alone
Design
Multicenter open-label superiority randomized controlled trial
Follow-up
1 year
Authors
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LVA ablation plus PVI does not reduce AF/AT recurrence versus PVI alone; challenges routine substrate modification and leaves open subgroup selection by remodeling severity.
RCT (n=340)
Open-label
1:1
Yes
Does left atrial low-voltage area guided ablation in addition to pulmonary vein isolation reduce the recurrence of atrial fibrillation in patients with persistent atrial fibrillation and low-voltage areas?
The SUPPRESS-AF trial is designed to determine if adding LVA-guided ablation to PVI improves 1-year freedom from AF recurrence in patients with persistent AF.
Sunaga et al. (2021) conducted an RCT in Persistent atrial fibrillation (n=340). Left atrial low-voltage area guided ablation in addition to pulmonary vein isolation vs. Pulmonary vein isolation alone was evaluated on Recurrence of atrial fibrillation documented by scheduled or symptom-driven electrocardiography during the 1 year follow-up period. Left atrial low-voltage area guided ablation in addition to pulmonary vein isolation is being evaluated for superiority against pulmonary vein isolation alone in a planned trial of 340 patients with persistent atrial fibrillation.
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