What question did this study set out to answer?

Determine whether dried blood spots from fingerstick sampling can reliably quantify SARS-CoV-2 neutralising antibody responses compared to standard paired sera.

September 11, 2023ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

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Authors

KRKelly J. RoperUniversity of Liverpool JTJordan ThomasUniversity of Liverpool WAWejdan AlbalawiJouf University

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Implication

Validation study reveals strong agreement of SARS-CoV-2 neutralising antibody levels between dried blood spots and paired sera, indicating a viable tool for decentralized serosurveillance.

Key Points

Determine whether dried blood spots from fingerstick sampling can reliably quantify SARS-CoV-2 neutralising antibody responses compared to standard paired sera.
Collected fingerstick blood, venous blood, and paired sera on filter paper across three cohorts: individuals with acute SARS-CoV-2 infection, convalescent individuals, and vaccinated individuals.
Eluted dried blood spots and quantified neutralising antibody responses, assessing sample stability in filter paper stored at room temperature for 28 days.
Demonstrated good agreement in measured neutralising antibody responses between eluted dried blood spots and matched paired sera across all cohorts.
Maintained stable neutralising antibody responses in sera stored on filter paper at room temperature for up to 28 days.

Cite This Study

Roper et al. (2023) studied this question.

synapsesocial.com/papers/6a990b6424d3faa49b749946 https://doi.org/10.1038/s41598-023-41928-2

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Implication

Validation study reveals strong agreement of SARS-CoV-2 neutralising antibody levels between dried blood spots and paired sera, indicating a viable tool for decentralized serosurveillance.

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

Discussion

Member takes

Implication

Key Points

Cite This Study

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

Discussion

Member takes

Implication

Key Points

Cite This Study

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