Key result
Hypertension and male sex were associated with significantly greater mean carotid intima-media thickness (by 28.29 µm and 24.07 µm, respectively; both P<0.001) in asymptomatic elders.
Why the study?
To examine the mean carotid intima-media thickness (CIMT) and identify potentially relevant determinants of increased CIMT in elderly individuals.
Cross-Sectional (n=1,039)
In asymptomatic elders in rural China, male sex, older age, and hypertension are significant determinants of increased carotid intima-media thickness.
Answers are grounded in this paper and cite their sources.
Supports male sex and hypertension associations with CIMT in rural elders; hypothesis-generating, prospective studies needed before clinical use.
Objective: To examine the mean carotid intima-media thickness (CIMT) and potentially relevant determinants of increased CIMT in elders.Method: Stroke-free and cardiovascular disease-free residents aged ≥65 years were recruited in a low-income population in China. B-mode ultrasonography was performed to measure CIMT.Results: A total of 1039 individuals (47.9% men) were recruited. The mean CIMT value was 0.60 (SD: 0.09) mm. The mean CIMT was 24.07 (SEM: 6.52) µm greater in men than in women (P < 0.001) and 28.29 (SEM: 7.47) µm greater in patients with hypertension than in those without hypertension (P < 0.001). Moreover, the mean CIMT increased by 1.53 (SEM: 0.49) µm for each 1-year increase in age (P = 0.002). However, the mean CIMT decreased by 5.55 (SEM: 2.40) μm and 6.45 (SEM: 2.62) μm for every 1-mmol/L increase in triglyceride concentration and the high-density lipoprotein cholesterol: low-density lipoprotein cholesterol ratio, respectively (P < 0.05). However, high triglyceride level was negatively associated with mean CIMT only among individuals without metabolic syndrome (P = 0.036).Discussion: These findings suggest that there is an urgent need to delay atherosclerosis progression and reduce the stroke burden by managing hypertension, especially for men. Moreover, to decrease the stroke burden in rural China, caution is advised regarding lipid-lowering treatment in elderly patients without metabolic syndrome.
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Yu et al. (2020) conducted a cross-sectional in Asymptomatic (n=1,039). Hypertension vs. No hypertension was evaluated on mean carotid intima-media thickness (CIMT) (MD 28.29 µm, p=<0.001). Hypertension and male sex were associated with significantly greater mean carotid intima-media thickness (by 28.29 µm and 24.07 µm, respectively; both P<0.001) in asymptomatic elders.
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